Therapeutic Androgen Receptor Ligands
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چکیده
منابع مشابه
Therapeutic androgen receptor ligands
In the past several years, the concept of tissue-selective nuclear receptor ligands has emerged. This concept has come to fruition with estrogens, with the successful marketing of drugs such as raloxifene. The discovery of raloxifene and other selective estrogen receptor modulators (SERMs) has raised the possibility of generating selective compounds for other pathways, including androgens (that...
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Endocrine disruptors are hormone mimics that modify hormonal action in humans and animals. It is thought that some endocrine disruptors modify estrogen and androgen action in humans and animals by suppressing aromatase activity. Aromatase cytochrome P450 is the key enzyme that converts C19 androgens to aromatic C18 estrogenic steroids. We have developed a novel aromatase inhibitor screening met...
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ژورنال
عنوان ژورنال: Nuclear Receptor Signaling
سال: 2003
ISSN: 1550-7629
DOI: 10.1621/nrs.01009